Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Ophthalmologe 97 (2000), S. 609-614 
    ISSN: 1433-0423
    Keywords: Schlüsselwörter Pseudophakieablatio ; Funktionelles Ergebnis ; Schrittweise Regressionsanalyse ; Pars-plana-Vitrektomie ; Silikonöltamponade ; Keywords Pseudophakic retinal detachment ; Visual outcome ; Stepwise regression analysis ; Pars plana vitrectomy ; Silicone oil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background. Pseudophakic retinal detachment is one of the most severe complications after retinal detachment and is a common cause of permanent reduction in visual acuity. We evaluated parameters predicting reduced functional outcome by a model of stepwise regression analysis. Patients and Methods. A series of 102 consecutive patients with pseudophakic retinal detachment were analyzed for various parameters regarding cataract surgery, retinal surgery, and retinal detachment features. First, univariate analyses determined the correlations with reduced functional outcome. Secondly, a stepwise regression model analyzed statistically significant variables for their predictive value of a reduced visual outcome. Results. The overall reattachment rate was 99%. In 69% of the patients there was an improvement of more than two lines at the end of the follow-up period. The most predictive factors for reduced functional outcome were the need for a silicone oil tamponade and the visual acuity prior to retinal detachment surgery. When silicone oil tamponade was not needed, the requirement of more than two retinal surgeries was the most predictive factor for reduced visual outcome. Conclusion. In our series the strongest predictive factors for a reduced functional outcome were the necessity of silicone oil, reduced visual acuity at the time of retinal detachment, and the requirement of more than two retinal surgeries. These findings suggest that as the first-line procedures should not be a minimally invasive measurement but rather procedures that result in a stably attached retina in the first instance without permanent silicone oil tamponade, even if this first operation consists of a extended pars plana vitrectomy.
    Notes: Zusammenfassung Hintergrund. Die Ablatio retinae stellt eine der schwersten Komplikation nach Kataraktextraktion dar, da sie häufig mit einer deutlichen und dauerhaften Visusreduktion einhergeht. In dieser Studie sollen durch Anwendung einer Multifaktorenanalyse die Parameter analysiert werden, die die Vorhersage einer reduzierten Visusprognose erlauben. Patienten und Methoden. Es wurden 102 konsekutive Patienten mit einer Pseudophakieablatio retrospektiv hinsichtlich verschiedener Parameter der Katarakt-, Netzhautoperation und des Ablatiobefundes untersucht. Der mittlere Nachbeobachtungszeitraum betrug 14 Monate. In einem 1. Schritt wurden alle Parameter einzeln einer Varianzanalyse hinsichtlich des erreichten Visus unterzogen. In einem 2. Schritt erfolgte eine schrittweise multifaktorielle Analyse der signifikanten Parameter. Ergebnisse. Die kummulative Wiederanlegungsrate lag bei 99%. Einen Visusanstieg um mindestens 2 Zeilen erreichten 69%. Die Notwendigkeit einer dauerhaften Silikonöltamponade sowie ein schlechter Ausgangsvisus stellen die wichtigsten Parameter hinsichtlich einer reduzierten Visusprognose dar. Betrachtet man eine Untergruppe ohne Silikonöltamponade, so sind mehr als 2 netzhautchirurgische Eingriffe der wichtigste prognostische Faktor für ein schlechtes Visusergebnis. Schlussfolgerung. Nach den Ergebnissen unserer Studie ist nicht unbedingt das minimal-invasive Operationsverfahren die Therapie der Wahl, sondern das Operationsverfahren, das mit der geringsten Anzahl an netzhautchirurgischen Eingriffen zu einer stabilen Wiederanlage der Netzhaut ohne dauerhafte Silikonöltamponade führt. Es muss somit individuell entschieden werden, welches operative Verfahren als Ersteingriff am Erfolg versprechendsten erscheint, auch wenn dieser Ersteingriff ein ausgedehnted vitreoretinales Vorgehen erfordert.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-0851
    Keywords: Key words Gene therapy ; Melanoma ; Vaccination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  From January 1994 to July 1996 we immunized metastatic melanoma patients with HLA-A2-compatible, interleukin-2 (IL-2)-secreting, immunogenic melanoma lines in an attempt to induce a systemic reaction that might also affect distant melanoma lesions. Twelve patients (6 male and 6 female) aged from 28 to 72 years, affected with visceral and/or subcutaneous (s.c.) melanoma metastases, were treated. Two different HLA-A2+ melanoma lines were transduced with the human IL-2 gene (14932/IL-2 and 1B6/IL-2) and used as vaccine. Two groups of 4 patients each were injected s.c. with 5×107 and 15×107 irradiated 14932/IL-2 melanoma cells respectively, whereas a third group received 5×107 cells of the second line (1B6/IL-2). All patients received the vaccine on days 1, 13, 26; if no progression was evident, further immunizations were administered at monthly intervals. All patients were assessable for clinical response after at least three injections of the vaccine. In 4 cases a stabilization of disease lasting from 2 to 6 months was observed; in 2 of them a mixed type of response to treatment was noted with simultaneous evidence of regressing and non-responding lesions in the same patients. No signs of clinical response were found in the remaining patients. Nine patients died of disease between 3 and 24 months after the onset of therapy, whereas 3 were alive 3 months after the end of therapy. The local and systemic side-effects of treatment were mild. These results indicate that vaccination with cells bearing the appropriate antigens and releasing IL-2 locally can produce weak clinical responses, but also indicate that better results may be achieved through modifications of the vaccine, the schedule of immunization and/or a more appropriate selection of patients.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...