ISSN:
1432-2307
Keywords:
Clear cell sarcoma
;
Melanosomes
;
Cytochemistry
;
Electron microscopy
;
Nude mouse
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In order to clarify the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS), two cases of human and one nude mouse-transplanted CCS line were studied using an ultrastructural and enzyme cytochemical approach. Most of the tumour cells obtained from the primary and transplanted CCS demonstrated melanosomes in various stages of development within the cytoplasm, whereas no melanosomes could be identified in the metastatic CCS. However, cholinesterase and tyrosinase activities could be demonstrated not only in the melanotic primary and transplanted CCS but also in the amelanotic metastatic CCS. The results therefore support the hypothesis that CCS is a soft tissue tumour derived from the neural crest.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00718604
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