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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 24 (1972), S. 331-346 
    ISSN: 1432-2072
    Keywords: Tryptamine ; Hallucinations ; Schizophrenia ; Serotonin ; Melatonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A modification of the method of Hess and Udenfriend (1959) for the extraction and identification of tryptamine, as well as a gas chromatographic method for identifying tryptamine, has been described. Tryptamine, using these methods, as well as thin layer chromatography, has been identified in steer, dog and human brain. Tryptamine was not found in the rat brain. In the dog, isocarboxazid increased brain and spinal cord tryptamine levels two or three times. In view of the fact that tryptamine resembles LSD-like hallucinogens in many of its actions, it is suggested that tryptamine may be a naturally occurring hallucinogen that may play a role both in normal and pathologic functioning of the brain.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Tryptamine ; Spinal Cord ; Facilitation ; Neurotransmitters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The brain and spinal cord of the chronic spinal dog contained higher levels of tryptamine than comparable regions of the intact dog. The most significant brain elevations were found in the cerebellum and mesencephalon. Further, tryptamine in the white matter of the spinal cord above the level of transection was higher than below. These findings have been interpreted as indicating that there are tryptaminergic pathways descending in the white matter of the spinal cord from the mesencephalon, cerebellum and rostral spinal cord. The level of tryptamine below the transection was not different from that found in the intact dog, suggesting that there are not only descending but ascending tryptaminergic pathways and that when the axons are transected, tryptamine accumulates proximal to the level of transection.
    Type of Medium: Electronic Resource
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