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  • 1
    Electronic Resource
    Electronic Resource
    Nitric Oxide Participates in the Stimulatory and Neurotoxic Action of Endothelin on Rat Striatal Dopaminergic Neurons (1997)
    Springer
    Cellular and molecular neurobiology 17 (1997), S. 471-481 
    Details
    ISSN: 1573-6830
    Keywords: nitric oxide ; N G-methyl-L-arginine ; endothelin-3 ; dopamine release ; neurotoxicity ; rat striatal slices
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. Our method of real-time monitoring of dopamine release from rat striatal slices revealed that endothelin (ET)-3-induced dopamine release was inhibited by N G-methyl-L-arginine (L-NMMA; 1 mM), an inhibitor of nitric oxide (NO) synthase, while N G-methyl-D-arginine (D-NMMA; 1 mM), an inactive isomer of L-NMMA, had no effect. 2. The inhibition of L-NMMA (0.1 mM) became apparent when tissues were pretreated with tetrodotoxin (1 μM) for 30 min and subsequently exposed to ET-3 (4 μM). 3. L-NMMA (0.1 and 1 mM) dose dependently protected against ET-3-triggered hypoxic/hypoglycemic impairment of striatal responses to high K+. 4. Thus, NO may work as a promoter in mediation of the stimulatory and neurotoxic action of ET-3 on the striatal dopaminergic system, presumably by interacting with interneurons in the striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026354720732
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  • 2
    Electronic Resource
    Electronic Resource
    Involvement of Glial Cells in Cyclosporine-Increased Permeability of Brain Endothelial Cells (2000)
    Springer
    Cellular and molecular neurobiology 20 (2000), S. 781-786 
    Details
    ISSN: 1573-6830
    Keywords: cyclosporine ; neurotoxicity ; glia@keyword = blood–brain barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract SUMMARY 1. To test whether astrocytes participate in cyclosporine-induced dysfunction of the blood-brain barrier, we examined the effects of cyclosporine on the permeability of the mouse brain endothelial (MBEC4) cells cocultured with C6 glioma cells, each cell layer placed on the top and bottom of the insert membrane, respectively. 2. The presence of C6 cells remarkably aggravated cyclosporine-increased permeability of MBEC4 cells to sodium fluorescein. 3. In light of these findings, the possibility that astroglial cells could contribute to the occurrence of cyclosporine-induced dysfunction of the blood-brain barrier triggering neurotoxicity should be considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007015228318
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Quality evaluation by capillary electrophoresis of amphotericin B injection after filtration through various membrane filters (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 2930-2934 
    Details
    ISSN: 0173-0835
    Keywords: Amphotericin B ; Fungizone ; Membrane filter ; Micellar electrokinetic capillary chromatography ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: The determination of amphotericin B, an antifungal agent, was developed using micellar electrokinetic capillary chromatography (MEKC) with a diode array detector. Repeatability and intermediate precision of MEKC analysis were acceptable. A high correlation was found between amphotericin B levels in pharmaceutical solutions obtained by MEKC and those by high-performance liquid chromatography (HPLC) (r = 0.994). This MEKC method is therefore useful for the determination of amphotericin B. The concentration of amphotericin B did not significantly change after filtration through polyethersulfone (PES, 0.2 μm) and polyvinylidene difluoride (PVDF, 0.45 μm) membrane filters. When the Fungizone injection was filtered through PES (0.2 μm) and added to 5% dextrose for injection (500 mL), particulate matters larger than 10 μm decreased by 64% to a level under the standard defined by United States Pharmacopoeia (USP XXIII). PVDF filtration (0.45 μm) did not have this effect. Our results suggest that filtration of Fungizone injection through PES (0.2 μm) membrane filters is recommended for the preparation of intravenous amphotericin B fluid.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150191622
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    Paper (German National Licenses)
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