ISSN:
1432-2072
Keywords:
Methylphenidate
;
Hyperkinesis
;
Mesencephalic Reticular Formation
;
Thalamus
;
Attention
;
Arousal
;
CNS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Intravenous administration of methylphenidate (1 or 2 mg/kg) markedly attenuated the unit discharge rate in the mesencephalic reticular formation of rats and cats. Concurrently this drug enhanced the neural activity in the primary sensory nuclei of the thalamus. The differential effects of methylphenidate on these two neural systems suggest a possible mechanism by which it may improve attentive processes in hyperkinesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421176
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