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  • 1
    Electronic Resource
    Electronic Resource
    Measurement of nitrosodimethylamine by capillary gas chromatography-mass spectrometry with the 15N-labelled compound as an internal standard (1984)
    Springer
    International archives of occupational and environmental health 54 (1984), S. 233-239 
    Details
    ISSN: 1432-1246
    Keywords: Nitrosamine ; Mass spectrometry ; Internal standard ; Nitrogen dioxide ; Sulfur trioxide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Artifactual formation of N-nitrosodimethylamine during the extraction procedure from aminopyrine and nitrite was examined. The use of the basic pH condition was the most effective in preventing artifactual formation. Sulfamic acid or ascorbic acid was partially effective in preventing artifactual formation. Since significant losses of volatile N-nitrosodimethylamine occur during the extraction and concentration steps, we analyzed N-nitrosodimethylamine by combined gas chromatography mass spectrometry with 15N-nitrosodimethylamine as an internal standard. The use of a fused silica capillary column enabled us to obtain a fine separation of the chromatogram. This methodology was applied to our model experiment, which was performed to locate the formation of N-nitrosodimethylamine when a rabbit was exposed to NO2 after the administration of aminopyrine. SO3 inhaled together with NO2 was found to increase the nitrosation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00379052
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vivo studies on methemoglobin formation by sodium nitrite (1980)
    Springer
    International archives of occupational and environmental health 45 (1980), S. 97-104 
    Details
    ISSN: 1432-1246
    Keywords: Nitrite ; Methemoglobin ; Nitrosyl hemoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45–80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274129
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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