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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 281 (1989), S. 95-98 
    ISSN: 1432-069X
    Keywords: Methyl nicotinate ; Percutaneous absorption rates ; Microcirculatory sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of human skin to topical methyl nicotinate (MN) has been monitored in black, oriental, and caucasian subjects. The study aimed to address the question: “Do racial differences in percutaneous absorption and microcirculatory sensitivity exist?” MN-induced vasodilation was assessed visually and by laser Doppler velocimetry (LDV). At three dose levels, in the three subject populations, four parameters were compared: (a) the diameter of the maximum visually perceptible erythematous area (Emx); (b) the area under the erythematous diameter versus time curve (AUE); (c) the maximum LDV response (Lmx); and (d) the area under the LDV response versus time curve (AUL). At p〈0.05, AUL (black)〉AUL (caucasian) for all MN concentrations; AUL (oriental)〉AUL (caucasian) for the higher dose levels. Emx, AUE and Lmx showed no significant differences between races within concentrations. For all subjects, Emx AUE, and AUL were significantly dependent on MN dose whereas Lmx was not. The results suggest that some racial differences in response to topical MN exist and that perception of these distinctions may depend upon the method of measurement.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 273 (1982), S. 91-95 
    ISSN: 1432-069X
    Keywords: Methyl nicotinate ; Radial spread ; Dermis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Topical application of a sufficiently concentrated aqueous solution of methyl nicotinate elicits within minutes an erythematous, vasodilatory response in humans. In this study the radial increase of the erythematous area visible in the skin has been followed as a function of solution application time and methyl nicotinate concentration. Because of the nature of the physiological response, the observations are interpreted in terms of the dermal movement of the drug. The rate of radial spread was much more rapid than can be accounted for in terms of simple diffusion, and a mechanism involving transport by the blood flowing in the dermal vasculature is proposed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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