ISSN:
1432-1041
Keywords:
Miconazole nitrate
;
antifungal
;
Candida spp
;
dermatophytosis
;
safety
;
biotransport and biotransformation
;
nystatin
;
tetracycline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Miconazole nitrate was investigated in 169 normal volunteers for its safety and its antifungal action on the bronchial and intestinal flora after oral administration, and for its biotransport and transformation after oral, intravaginal and percutaneous administration. — Oral doses of 3 g a day for nine weeks produced no haematological, biochemical or ECG abnormalities. Within the first week of treatment, miconazole significantly reduced the number of fungal colonies in cultures of sputum and faeces, and inhibited tetracycline-induced fungal overgrowth in the faeces. Oral miconazole significantly improved dermatophytosis. — Miconazole was absorbed moderately well from the gastrointestinal tract and was virtually not absorbed from the mucous membrane and skin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00561752
Permalink
