ISSN:
1040-0397
Keywords:
Microelectrodes
;
Enzyme electrodes
;
Neurochemical measurements
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Various approaches to the production of miniaturized chemical sensors for in vivo applications are reviewed with special regard to the measurement of chemical transients in the mammalian brain. The basic tenants of biosensor principles are discussed in terms of the temporal response of enzyme-modified electrodes and selection of redox enzymes. The effects of electron transfer mediators and differential measurements to gain selectivity are also examined. A broad range of immobilization methods including membrane entrapment, physical and chemical adsorption, cross-linking agents, polymeric entrainment, electropolymerized films and covalent derivatization are examined. The use of polymer layers and redox polymers to gain selectivity are discussed. The discussion is limited to microelectrode surfaces (〈 100 μm diameter) and various electrode types are examined, including bare and platinized carbon fibers, platinum microelectrodes, conducting organic salts and carbon paste electrodes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140070502
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