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  • 1
    Electronic Resource
    Electronic Resource
    Vascular permeability of the middle ear mucosa in otitis media with effusion (1987)
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1987), S. 218-221 
    Details
    ISSN: 1434-4726
    Keywords: Otitis media with effusion ; Protease inhibitors ; Vascular permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vascular permeability (VP) of the middle ear mucosa (MEM) in chronic otitis media with effusion (OME) was estimated in both pediatric and adult patients by calculating the middle ear effusion (MEE) to serum concentration ratios of albumin and of four protease inhibitors: α1-antitrypsin (α1-AT), α1-antichymotrypsin (α1-X), inter-α-trypsin inhibitor (I-α-I) and α2-macroglobulin (α2-M). The levels of albumin and α1-AT in MEE were higher while those of I-α-I and α2-M were lower than their serum levels in both adult serous and pediatric mucoid groups. There was a negative correlation between molecular weight and the mean value of the ratio (MEE/serum) of the four inhibitors in both serous (r=−0.989) and mucoid (r=−0.924) groups. Vascular permeability of the MEM seems to be variable in both serous and mucoid groups during middle ear inflammation. Selective leakage of proteins by molecular weight appears to occur in MEM. Our findings further indicate that a high level of the high-molecular-weight inhibitor α2-M in MEE may be a significant index reflecting the remarkably enhanced VP of the MEM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455309
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The relationship between antigen levels and middle ear inflammation in antigen-induced otitis media in the chinchilla (1988)
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 42-46 
    Details
    ISSN: 1434-4726
    Keywords: Antigen-induced otitis media ; Human serum albumin ; Middle ear effusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between antigen levels in middle ear effusions (MEE) and the degree of middle ear inflammation was studied in an antigen-induced otitis media model, using chinchillas sensitized with human serum albumin (HSA). The degree of middle ear inflammation was evaluated by both tympanometric analysis, and cytological and biochemical analyses of the MEE. Middle ear inflammation develops after HSA challenge with a remarkable decrease in HSA levels in the MEE. This inflammation persists even when HSA levels are no longer detectable in the MEE. These findings show that local challenges with an antigen induce a certain degree of middle ear inflammation, which continues even after complete elimination of the antigen from the middle ear through an immunological defense mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463547
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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