ISSN:
1617-4623
Keywords:
Translational activation
;
Cytochrome b
;
Mitochondria
;
Yeast
;
CRS1
;
CBS2
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The products of the nuclear genes CBS1 and CBS2 are both required for translational activation of mitochondrial apocytochrome b in yeast. We report the intramitochondrial localization of both proteins by use of specific antisera. Based on its solubilization properties the CBS1 protein is presumed to be a component of the mitochondrial membrane; the detergent concentrations needed to release CBS1 from mitochondria are almost the same as for cytochrome c 1. In contrast, CBS2 behaves like a soluble protein, with some characteristics of a membrane-associated protein. A model is presented for translational activation of cytochrome b, which might also be applicable to translational regulation of other mitochondrial genes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00290666
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