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  • Mn2+ accumulation  (1)
  • glial cells  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Combined effects of ethanol and manganese on cultured neurons and glia (1991)
    Springer
    Neurochemical research 16 (1991), S. 591-596 
    Details
    ISSN: 1573-6903
    Keywords: Ethanol ; manganese ; cell cultures ; neurons ; glial cells ; enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Manganese is essential for normal development and activity of the nervous tissue. Mn2+ ions are involved in protein synthesis and may prevent free radical damage. Since it is now established that alcohol degradation may produce free radicals, we studied the effect of Mn2+ on ethanol induced alterations using cultured nerve cells as an experimental model of the central nervous system. Neurons and glial cells were cultured from rat brain cortex; a tumoral rat glial cell line (C6) was also examined. We measured enzymatic markers of nerve cell maturation (enolase, glutamine synthetase) and superoxide dismutase, a scavenger of free radicals; all these enzymes being activated by Mn2+ ions. Only for the glial cell types an alcohol antagonizing effect was found when Mn2+ was combined with ethanol. Neurons were not sensitive to that Mn2+ effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00974879
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of Mn2+ accumulation in cultured rat neuronal and astroglial cells (1990)
    Springer
    Neurochemical research 15 (1990), S. 751-754 
    Details
    ISSN: 1573-6903
    Keywords: Glial cells ; Neurons ; Mn2+ accumulation ; K+-effect ; trace elements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of physiological concentrations of K+ on Mn2+ accumulation were compared in rat glial cells and neurons in culture. Increasing the K+ concentration in growth medium increased significantly the Mn2+ level of the cultivated cells, with glial cells more affected than neurons. Ethanol markedly increased the Mn2+ accumulation within glia but not within neurons while ouabaïn caused inhibition of Mn2+ uptake with neurons and glial cells. A modulation of the total protein synthesis by Mn2+ and ethanol level in the growth medium was observed with glial cells. These data suggest that the mechanisms involved in Mn2+ accumulation in glial cells are different from those present in neurons. Moreover, the results are consistent with the hypothesis that Mn2+ plays a regulatory role in glial cell metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00973657
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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