ISSN:
1432-2072
Keywords:
Key words 5-HT1A-receptors
;
Positron emission tomography
;
Monkey brain
;
[Carbonyl-11C]WAY-100635
;
8-OH-DPAT
;
Buspirone
;
Pindolol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract [carbonyl- 11C]WAY-100635 is a new radioligand which can be used with positron emission tomography (PET) to provide high contrast delineation of human brain regions that are rich in 5-HT1A receptors. In the present PET study, the binding of [carbonyl- 11C]WAY-100635 was characterized in the cynomolgus monkey brain. Pretreatment with each of the two reference compounds, WAY-100635 and 8-OH-DPAT, as well as the drugs buspirone and pindolol, induced a marked inhibition of [carbonyl-11C]WAY-100635 binding in the neocortex and the raphe nuclei. A preliminary Scatchard analysis yielded 5-HT1A receptor density values of the same order as those that have been reported in vitro. The study shows that [carbonyl- 11C]WAY-100635 binds specifically to 5-HT1A receptors in the primate brain and has potential for determination of 5-HT1A receptor occupancy and density in psychiatric patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002130050391
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