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  • Positron emission tomography  (6)
  • Monoamine oxidase type B  (1)
  • Recognition memory  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Neural correlates of depth of processing effects on recollection: evidence from brain potentials and positron emission tomography (1998)
    Springer
    Experimental brain research 123 (1998), S. 18-23 
    Details
    ISSN: 1432-1106
    Keywords: Key words Event-related potentials ; Hippocampus ; Positron emission tomography ; Recognition memory ; Retrieval
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The probability that words would be recollected during tests of recognition memory was varied by manipulating depth of processing at study. Experiment 1 employed scalp-recorded event-related potentials (ERPs), and identified as a correlate of recollection a late (onset c. 500 ms), strongly left-lateralized positive-going modulation of the ERP waveform. The findings from experiment 2, which employed positron emission tomography (PET), indicated that recollection was associated with activation of the left hippocampal formation together with an extensive region of left temporal and frontal cortex. The findings support current ideas about the role of the hippocampal formation in episodic memory retrieval, and provide complementary information about the time course and localization of the cortical correlates of the recollection of recently experienced words.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050540
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The time course of binding to striatal dopamine D2 receptors by the neuroleptic ziprasidone (CP-88,059-01) determined by positron emission tomography (1996)
    Springer
    Psychopharmacology 124 (1996), S. 141-147 
    Details
    ISSN: 1432-2072
    Keywords: Positron emission tomography ; Pharmacokinetics ; 11C-Raclopride ; Dopamine D2 receptors ; Ziprasidone ; CP-88,059-1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Positron emission tomography (PET) and11C-raclopride were used to assess the time course of binding to central dopamine D2 receptors by the novel neuroleptic ziprasidone. In a third party blind study, six healthy male control subjects received a predose of 40 mg ziprasidone and were scanned at an interval of between 4 and 36 h post-dose. One additional subject was assigned to placebo predose and was scanned at 4 h post-dose. Binding potential (BP) was compared with that seen in the subject predosed with placebo and with that seen in nine unmedicated normal volunteers. Subjects studied up to 12 h post-dose had BPs that were greater than 2 SD less than the mean BP, indicative of extensive D2 receptor binding by ziprasidone. With increasing time between dosing and PET scanning there was a curvilinear increase in BP, so that all studies performed at or after 18 h post-dose gave BPs in the normal range (mean±2 SD). Elevated prolactin levels returned to within the normal range by 18 h post-dose. PET measures of binding potential correlated significantly with serum levels of ziprasidone at the time of scanning and less significantly with absolute prolactin levels at the same time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245614
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task (1995)
    Springer
    Experimental brain research 104 (1995), S. 337-348 
    Details
    ISSN: 1432-1106
    Keywords: Scopolamine ; Memory ; Positron emission tomography ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Scopolamine, a muscarinic antagonist, impairs memory performance in both humans and animals. In this study, repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers whilst performing auditory verbal memory tasks, before and after the administration of scopolamine (0.4 mg s.c.) or placebo. Compared to placebo, scopolamine increased blood flow in the lateral occipital cortex bilaterally and the left orbitofrontal region. Scopolamine decreased rCBF in the region of the right thalamus, the precuneus and the right and left lateral premotor areas. Scopolamine attenuated memory-task-induced increases of rCBF in the left and right prefrontal cortex and the right anterior cingulate region. These data suggest that acute blockade of cholinergic neurotransmission affects diverse brain areas, including components of the visual and motor systems, and, in addition, modulates memory task activations at distinct points in a distributed network for memory function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00242019
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Measurement of human cerebral monoamine oxidase type B (MAO-B) activity with positron emission tomography (PET): a dose ranging study with the reversible inhibitor Ro 19-6327 (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 169-173 
    Details
    ISSN: 1432-1041
    Keywords: Monoamine oxidase type B ; Positron emission tomography ; Ro 19-6327 ; Pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight normal subjects (3 females and 5 males) were studied using intravenous L-11C] deprenyl and positron emission tomography. In a single blind study one subject received tracer alone, one subject received an oral pre-dose of 20 mg of L-deprenyl and 6 subjects received oral pre-doses of 10 to 50 mg of a novel reversible MAO-B inhibitor (Ro 19-6327). Dynamic PET scans beginning 12 h after the oral dose were collected over 90 min and arterial blood was continuously sampled. Data analysis was modelled for two tissue compartments and using an iterative curve fitting technique the value of the rate constant for irreversible binding of L-[11C] deprenyl to MAO-B (k3) in whole brain was obtained for each subject. The dose response curves obtained indicated that a dose of at least 0.48 mg·kg−1 of Ro 19-6327 was necessary for 〉90% decrease in whole brain k3. Inhibition of MAO-B in platelets isolated from blood samples taken at the time of scanning correlated strongly with decrease in whole brain k3 (r=0.949). The results indicate that PET can be used to determine the dose of Ro 19-6327 necessary to inhibit 〉90% of brain MAO-B. This technique is an attractive alternative to traditional large scale patient-based dose-finding studies. Moreover it is shown that inhibition of platelet MAO-B can be used as a marker for central MAO-B inhibition with Ro 19-6327.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280072
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Dose dependent occupancy of central dopamine D2 receptors by the novel neuroleptic CP-88,059-01: a study using positron emission tomography and11C-raclopride (1993)
    Springer
    Psychopharmacology 112 (1993), S. 308-314 
    Details
    ISSN: 1432-2072
    Keywords: Positron emission tomography ; Pharmacodynamics ; 11C-raclopride ; Dopamine D2 receptors ; CP-88,059-1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Positron emission tomography (PET) and11C-raclopride were used to measure the occupancy of central dopamine D2 receptors by a new neuroleptic, CP-88,059-1. In a double blind dose escalation study, seven healthy male subjects received a predose of between 2 mg and 60 mg CP-88,059-1, 5 h before PET scanning. One additional subject was assigned to placebo predose. Receptor occupancy was defined as the percentage reduction in binding potential compared with that seen in the subject predosed with placebo and with that seen in seven unmedicated normal volunteers previously studied. Binding of11C-raclopride decreased in a dose dependent manner, and 85% dopamine D2 receptor occupancy was achieved with the highest dose of CP-88,059-1. The findings confirm that brain dopamine D2 receptors are blocked by CP-88,059-1 and suggest that an effective antipsychotic dose will be between 20 mg and 40 mg. The study highlights the potential of positron emission tomography in the preclinical evaluation of new drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244926
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man (1992)
    Springer
    Psychopharmacology 108 (1992), S. 380-386 
    Details
    ISSN: 1432-2072
    Keywords: Buspirone ; 5-HT1A receptors ; Positron emission tomography ; Statistical parametric mapping ; Pharmacological challenge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of the 5-HT1A partial agonist, buspirone, or placebo. The difference in rCBF, before and after drug, (buspirone versus placebo) was used to identify brain areas affected by buspirone. Buspirone-induced changes in rCBF were studied under two behavioural conditions (5 word-list learning and 15 word-list learning). Compared to placebo, buspirone increased blood flow in the cuneus during both behavioural states. However, decreases in blood flow, centred in the left dorso-lateral prefrontal cortex and posterior cingulate cortex, were only observed under one of the two behavioural conditions. It is concluded that buspirone-induced alterations in regional cerebral blood flow are better understood, not in relation to the known distribution of monoamine neurotransmitter systems (particularly ascending 5-HT projections), but rather in relation to putative neuronal circuits possibly many synapses “downstream” of buspirone's pharmacological site of action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245127
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    Paper (German National Licenses)
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