ISSN:
1432-0584
Keywords:
Monoclonal anti-T cell antibodies
;
Graft-versus-host reaction
;
Host-versus-graft reaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A new approach to avoid typical complications from bone marrow transplantation into MHC different mice was studied. Rat monoclonal anti-Thy-1 antibodies of the IgG2b isotype were identified, which inhibit T lymphocytes in vivo so that transplanted donor T cells as well as residual T cells of the conditioned marrow recipient were suppressed. A single injection of these antibodies after irradiation and before marrow transplantation did not only prevent graft-versus-host mortality but suppressed also host-versus-graft reactivity so that the radiation dose necessary for engraftment of donor cells differing in H-2, IA (both haplotypes) major histocompatibility antigens could be reduced to 6.0 Gy. In addition an anti-T leukemic cell effect from the injected monoclonal T cell antibodies was observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00321086
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