ISSN:
1437-160X
Keywords:
Interleukin
;
Monocytes/macrophages
;
Synovial fluid
;
Rheumatoid arthritis
;
Traumatic synovitis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Interleukin-1 (Il-1)-like activity in biological fluids was measured by their ability to rectify the Il-1-dependent lymphokine production of highly purified T lymphocytes to a recall antigen. Il-1-like activity was found in 9 of 11 synovial fluid (SF) specimens from patients with rheumatoid arthritis (RA) but only in 2 of 11 paired RA sera. In traumatic synovitis, low Il-1-like activity was recorded in 5 of 9 SF specimens, and a similar low activity was found in sera of 4 of these patients. The Il-1-like activity was partly absorbed by an anti-Il-1 antibody. The presence of Il-1 in the SF of patients with RA suggests in vivo activation of monocytes/macrophages.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00270301
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