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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 149 (2000), S. 286-292 
    ISSN: 1432-2072
    Keywords: Key words Cocaine ; Self-administration ; Sucrose ; Acquisition ; Fat ; Stress ; Substance ; Abuse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: A number of studies have indicated a relationship between the intake of palatable foods or fluids and drug self-administration. Objectives: Two experiments were conducted to determine whether the intake of sucrose or fat was related to subsequent cocaine self-administration. Methods: In separate groups of rats, sucrose or fat was presented for 60 min daily for 7 days. On day 8, a mild stressor (saline injection) was given just prior to sucrose or fat presentation. Rats were then catheterized and tested for cocaine self-administration on a fixed ratio schedule at doses from 0.2 mg/kg to 1.0 mg/kg per infusion and on a progressive ratio schedule at doses from 0.2 mg/kg to 1.5 mg/kg per infusion. Results: Sucrose intake after a mild stressor was significantly related to time to acquisition, with those rats consuming the most sucrose meeting the acquisition criterion sooner than those rats consuming lower amounts of sucrose. Subsequent to acquisition, however, low and high sucrose feeders did not consistently differ in the amount of cocaine self-administered. No relationship was observed between fat intake and rate of acquisition. Conclusion: These results provide additional evidence of a relationship between sucrose intake and drug reward, and suggest that stress reactivity may be an important component of this relationship.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of computer vision 44 (2001), S. 111-135 
    ISSN: 1573-1405
    Keywords: vision ; object location ; Monte Carlo ; filter-bank ; statistical independence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract A Bayesian approach to intensity-based object localisation is presented that employs a learned probabilistic model of image filter-bank output, applied via Monte Carlo methods, to escape the inefficiency of exhaustive search. An adequate probabilistic account of image data requires intensities both in the foreground (i.e. over the object), and in the background, to be modelled. Some previous approaches to object localisation by Monte Carlo methods have used models which, we claim, do not fully address the issue of the statistical independence of image intensities. It is addressed here by applying to each image a bank of filters whose outputs are approximately statistically independent. Distributions of the responses of individual filters, over foreground and background, are learned from training data. These distributions are then used to define a joint distribution for the output of the filter bank, conditioned on object configuration, and this serves as an observation likelihood for use in probabilistic inference about localisation. The effectiveness of probabilistic object localisation in image clutter, using Bayesian Localisation, is illustrated. Because it is a Monte Carlo method, it produces not simply a single estimate of object configuration, but an entire sample from the posterior distribution for the configuration. This makes sequential inference of configuration possible. Two examples are illustrated here: coarse to fine scale inference, and propagation of configuration estimates over time, in image sequences.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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