ISSN:
1432-2072
Keywords:
Ingestion
;
Morphine
;
Preference
;
Rat
;
Zimelidine
;
5-HT
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Zimelidine, a specific 5-HT uptake inhibitor, reduced peroral morphine consumption by morphine-addicted adult male and female Sprague-Dawley rats and old male rats in choice tests. The effect was dose dependent in male rats. Thus, the availability of central 5-HT appears to be important for the regulation of morphine preference in rat. The results are discussed in relation to recent literature where ethanol preference has been found to be attenuated by zimelidine. The results may provide insights into the complex cellular mechanisms underlying opiate addiction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426376
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