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Morphine ingestion: Genetic control in mice (1977)

Horowitz, G. P. ; Whitney, G. ; Smith, J. C. ; [et al.]

Springer

Psychopharmacology 52 (1977), S. 119-122

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ISSN: 1432-2072

Keywords: Morphine ingestion ; Mice ; Behavior genetics ; Saccharin

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract C57BL/6J mice will drink large amounts of, and display a highly positive preference for, morphine sulfate when it is dissolved in an aqueous solution of sodium saccharin. In identical test situations DBA/2J mice will drink very little of, and display a strong avoidance toward, the morphine-saccharin solution. This clear separation between morphine-accepting and morphine-rejecting animals within a single species combined with a quick and simple method of inducing high levels of morphine ingestion could facilitate the discovery of causal factors in opiate addiction.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00439097

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