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Perception of Genetic Risk Among Genetic Counselors (2000)

Roggenbuck, Jennifer ; Olson, Janet E. ; Sellers, Thomas A. ; [et al.]

Springer

Journal of genetic counseling 9 (2000), S. 47-59

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ISSN: 1573-3599

Keywords: Risk perception ; prenatal diagnosis ; genetic counselor attitudes

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine , Psychology

Notes: Abstract A mailed survey of female prenatal genetic counselors, obstetric nurses, and high school biology teachers was conducted to determine if these groups hold different attitudes toward genetic risk and to investigate the extent to which any differences result from the effect of different professional experiences. In this study, the participants were 166 genetic counselors, 116 obstetric nurses, and 78 biology teachers (n = 360). Survey participants completed a written questionnaire designed to assess their numeric estimate of the empiric risk for birth defects/genetic problems, their subjective perception of this risk, and their personal use of prenatal diagnosis. Genetic counselors were found to be less likely than the other groups to consider the frequency of birth defects/genetic problems as rare and were 10 times more likely than nurses and 8 times more likely than teachers to have had prenatal diagnosis. Furthermore, more than half of the prenatal diagnosis procedures had by genetic counselors were not medically indicated. These results suggest that genetic counselors have an increased perception of genetic risks relative to nurses or teachers. Possible explanations for this finding are discussed, and the potential role of discordant risk perception in creating biases in the genetic counseling process is explored.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1009481123596

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Multiplexed short tandem repeat polymorphisms of the Weber 8A set of markers using tailed primers and infrared fluorescence detection (1998)

Oetting, William S. ; Armstrong, Catherine M. ; Ronan, Shawn M. ; [et al.]

Weinheim : Wiley-Blackwell

Electrophoresis 19 (1998), S. 3079-3083

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ISSN: 0173-0835

Keywords: Multiplex polymerase chain reaction ; Tailed primers ; Gene mapping ; Short tandem repeat polymorphisms ; ODS ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Short tandem repeat polymorphism (STRP) markers have become important reagents for mapping genetic diseases. These markers are available as screening sets, which are located in all chromosomes at discrete intervals, allowing the entire genome to be analyzed. Mapping studies that include many individuals in the analysis necessitate the production of large numbers of genotypes. In an effort to increase the efficiency and lower the cost of using these STRP screening sets, we have divided the amplification primers of the Weber 8A screening set into groups that can be amplified in single polymerase chain reaction (PCR) amplification reactions, resulting in a reduction of both time and cost. Fluorescently-labeled amplification products were produced using a three primer reaction. The forward STRP amplification primer for each marker contained a 19 bp sequence at the 5′ end. A fluorescently-labeled primer, with a sequence identical to the 19 bp tail, was added to the amplification reaction as the sole source of fluorescent label. The STRP banding pattern is detected using an automated fluorescent DNA sequencer. Use of this multiplexed genomic screening set should greatly enhance the mapping of human disease loci.

Additional Material: 2 Ill.