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Chromatin self-organization by mutation bias (1994)

Holmquist, Gerald P.

Springer

Journal of molecular evolution 39 (1994), S. 436-438

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ISSN: 1432-1432

Keywords: Sequence evolution ; Mutation pressure ; Nucleosomes

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Proteins, on binding to a DNA sequence, alter the frequency and quality of mutations that occur in the sequence. This represents a reverse flow of information from proteins to DNA. Nucleosome binding causes patterns of UV-induced damage which, when converted to mutations by replication, will phase nucleosomes. We propose that DNA binding proteins create their own high- or low-affinity binding sites along DNA sequences by biased mutational pressure.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00173411

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