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  • 1
    Electronic Resource
    Electronic Resource
    Genotraumatic T cells and cutaneous T-cell lymphoma. A causal relationship? (1994)
    Springer
    Archives of dermatological research 287 (1994), S. 97-101 
    Details
    ISSN: 1432-069X
    Keywords: Genotraumatic T cells ; Cutaneous T-cell lymphoma ; Mycosis fungoides ; Sézary's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mycosis fungoides, or cutaneous T-cell lymphoma (CTCL), is a T-cell mediated chronic inflammatory skin disease, which can occasionally progress with a variable time course to a fatal lymphoma or to a leukaemic form called Sézary's syndrome. Extensive research into CTCL has not yet elucidated the primary pathophysiological mechanisms. Immunohistological studies are so far less helpful than expected in establishing early diagnosis and prognosis of the disease. The proposition that an exogenous virus is the cause of CTCL has not been substantiated. Karyotypic analysis of lymphocytes from the skin and blood of patients with CTCL have shown the existence of several genetically aberrant T-cell clones in the same patient. These changes are discussed as potential primary events for the development of CTCL. The hypothesis is put forward that the development of genotraumatic T lymphocytes is involved in the progression of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370726
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Natural and concanavalin A-induced cytotoxic activity towards continuously growing B lymphocytes derived from patients with cutaneous T-cell lymphoma (1986)
    Springer
    Archives of dermatological research 279 (1986), S. 12-15 
    Details
    ISSN: 1432-069X
    Keywords: Mycosis fungoides ; Sezary syndrome ; Concanavalin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Continuously growing T- and B-cell lines were derived from peripheral blood, affected skin, and lymph nodes of patients with mycosis fungoides (MF) and Sézary syndrome (SS). Two lymphoblastoid cell lines (MF-13 and SS-2) were Epstein-Barr virus (EBV)-transformed B cells evaluated by surface immunoglobulin, lack of E-rosette formation, positive EBV nuclear antibody test, and secretion of IgM antibody in a plaqueforming cell assay. Analysis of the natural-killer-cell activity using peripheral blood lymphocytes from patients with MF and healthy control persons towards MF-13 and SS-2 target cells suggested resistance to lysis even in tests supplemented with 1,000 IU/ml human γ-interferon. However, the cell lines were not per se completely resistant to lysis because lymphocytes from control persons showed significant cytotoxicity in an 18-h assay supplemented with 2 μg/ml concanavalin A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404351
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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