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  • Myofibrillar degeneration  (1)
  • cornea donors  (1)
  • genomic sequence  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Outbred mice infected by an encephalomyocarditis virus variant: A model for studying chronic viral heart disease (1993)
    Springer
    Virchows Archiv 422 (1993), S. 405-413 
    Details
    ISSN: 1432-2307
    Keywords: Encephalomyocarditis virus ; Virus-induced myocarditis ; Myofibrillar degeneration ; Myocarditis model ; Virus-induced cytolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male 8 to 20-week-old NMRI mice (an outbred strain) infected with the encephalomyocarditis virus (EMCV) plaque variant (PV) 7 consistently develop a distinct myocarditis with a relatively low mortality (21%). Myocarditis occurs in essence independent of the virus dose applied, and other internal organs are not affected. Nevertheless, 3.5-week-old NMRI mice perished within 5 days of virus inoculation and exhibited disseminated myofibrillar degeneration (MFD); this obviously virus-induced myocardial damage was accompanied by scanty inflammatory infiltrates. EMCV PV7 infection of adult male C57B1/6 and DBA/2 mice causes myocarditis comparable to that seen in NMRI mice. In DBA/2 mice, however, the virus-induced myocardial necrosis is complicated by subtotal calcification. This strain has a genetically determined “spontaneous” calcification of the myocardium, as shown by the study of uninfected controls. EMCV PV7-infected NMRI mice appear a promising model for study of long-term effects of viral myocarditis, possibly including cardiomyopathy. Furthermore, this outbred mouse strain offers the possibility of examining the pathogenesis of direct viral cytolysis and its relation to MFD as well as immunologically mediated cell damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605460
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of HIV in human vitreous (1993)
    Springer
    International ophthalmology 17 (1993), S. 101-104 
    Details
    ISSN: 1573-2630
    Keywords: AIDS ; cornea donors ; HIV antigen ; polymerase chain reaction ; retinal detachment ; vitreous
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Assay of human vitreous specimens obtained postmortem for HIV antibodies, or HIV p24 antigen, is reported to be a reliable technique to demonstrate HIV infection in possible cornea donors from whom serum could not be obtained. We tested three vitreous samples obtained during vitrectomy from two HIV-positive patients. One patient exhibited the clinical AIDS syndrome. HIV antigen and antibody tests were negative in all specimens. HIV proviral DNA was detected by PCR only in the vitreous of the patient with AIDS. Therefore, testing only vitreous samples is insufficient to exclude HIV infection in potential cornea donors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00942783
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular cloning and sequence determination of the complete genome of the virulent echovirus 9 strain Barty (1996)
    Springer
    Virus genes 12 (1996), S. 149-154 
    Details
    ISSN: 1572-994X
    Keywords: echovirus 9 ; genomic sequence ; RGD-motif ; pathogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As part of a study of the molecular basis of pathogenicity of echovirus 9, the complete nucleotide sequence of the mouse-virulent echovirus 9 strain Barty was determined. Excluding the poly(A) tail, the complete RNA genome is composed of 7451 bases. The postulated open reading frame extends from nucleotide (nt) 741 to 7349 and predicts a polyprotein of 2203 amino acids (aa). As compared with the sequence of the echovirus 9 prototype strain Hill, which is apathogenic for newborn mice, 1492 nt are exchanged, leading to 9% divergence of the deduced amino acid sequence. The foremost difference between both strains is located at the C-terminus of the capsid protein VP1. In the case of strain Barty, an additional 10 aa fragment, including an RGD motif, is inserted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572953
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    Paper (German National Licenses)
    Fulltext
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