ISSN:
1573-2592
Keywords:
Down's syndrome
;
binding affinity
;
N-acetylglucosamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Antibody binding data for naturally occurring anti-Group A streptococcal polysaccharide IgG, using the hapten, iodinated-GlcNAc, were determined by equilibrium dialysis for 22 institutionalizd subjects with Down's syndrome and for 23 non-Down's syndrome, institutionalized retardates. These data were compared to the binding data obtained from a group of 25 genetically normal, noninstitutionalized subjects. The number of antibody combining sites (N) was significantly higher in subjects with Down's syndrome than in either of the other groups. However, the binding affinity of Down's syndrome subject's anti-Group A streptococcal polysaccharide IgG was significantly lower than the binding affinities of the other groups of subjects. It is suggested that the lower binding affinity of IgG molecules of Down's syndrome subjects results in the commitment of more clones to the immune response; this may result in the increased serum levels of IgG seen in Down's syndrome subjects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00915145
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