ISSN:
1438-2199
Keywords:
NMDA receptors
;
Glutamate
;
Behaviour
;
MRZ 2/570
;
MRZ 2/576
;
L-701,324
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary It is not clear what therapeutic application is most likely for agents blocking glycine site of the NMDA receptors (glycineB). Majority of the studies to date used either glycineB antagonists with doubtful brain penetration or partial agonists. Following systemic administration to rats of our newly developed glycmeB antagonists (MRZ 2/570; 2/571 and 2/576) and L-701,324 (MSD) as a reference agent the following behavioural effects were observed: weak (if any) antiparkinsonian-like effects, lack of anxiolytic activity, inhibition of physical and motivational aspects of morphine dependence and neuroprotective activity in global ischaemia. The side effects include: sedation, ataxia, and myorelaxation. We detected neither vacuolisation in the cingulate cortex nor impairment of pre-pulse inhibition indicating lack of psychotomimetic potential.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01345268
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