ISSN:
1573-6903
Keywords:
Naftidrofuryl
;
neuronal cultures
;
survival
;
glucose transport lactate production
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The direct influence of Naftidrofuryl, a drug widely used for the treatment of cerebrovascular diseases, on the metabolism and survival of neurons was investigated in 8-day-old chick embryo forebrain cultures. Interaction of Naftidrofuryl with neurons resulted in the increase of the intracellular cyclic AMP levels. Naftidrofuryl stimulated deoxyglucose uptake and lactate production in a time- and dose-dependent fashion. These effects were observed after a few minutes following the beginning of the treatment with Naftidrofuryl. In parallel to the action on the metabolic activities, Naftidrofuryl was able to increase the survival rate of a significant proportion of the neuronal population. These data support the notion that Naftidrofuryl may act as a neuroprotective agent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00965509
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