ISSN:
1435-1536
Keywords:
Nanoparticles
;
polyalkylcyanoacrylates
;
photon correlation spectroscopy (PCS)
;
dextran
;
poloxamer
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Abstract The effect of dextran 40 and Poloxamer 188 as stabilizers in nanoparticle systems produced by dispersion polymerization is studied. Two different polymeric nanoparticle compositions are selected: polybutyl and polyisobutyl-2-cyanoacrylate. The parameters analyzed are the particle size and the polydispersity index which are determined by photon correlation spectroscopy. Results point out that the two polymers exhibit a nearly identical behavior. The action of both stabilizers is different and the addition of the two stabilizers together does not improve the particle size distribution of a nanoparticle system. The possible explanation of the different behavior is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00657453
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