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  • 1
    Digitale Medien
    Digitale Medien
    Bioavailability of indomethacin from a modified release system containing indomethacin as the lysine salt (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 85-87 
    Details
    ISSN: 1432-1041
    Schlagwort(e): indomethacin ; lysine salt ; controlled release formulation ; plasma concentration ; bioavailability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC was higher with the new controlled release formulation. The latter on average produced active plasma levels for 12 h, and so it can be recommended for twice daily administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00609963
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Natural killer cell activities of patients with breast cancer against different target cells (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 191-196 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Natural killer cell ; Breast carcinoma ; Target cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Natural killer (NK) cell activity against K 562 erythroleukemic- and MCF-7 breast carcinoma-derived cells was monitored in short-term (3h/ K 562) and long-term (18h/MCF-7) chromium release tests for 60 patients with untreated primary breast disease. Target cell lysis was the same for patient groups with benign (n=13) and malignant (n=47) breast disease (27% versus 36% mean chromium release; target: effector ratio 40:1 for K 562 and 28% versus 40% for MCF-7 cells). NK activity as defined by short-term lysis of K 562 cells did not correlate with MCF-7 cell lysis in long-term assays for the carcinoma patients. This functional heterogeneity of natural cytotoxic activities of breast cancer patients was confirmed by a different age distribution for K 562 and MCF-7 cell lysis and high levels of MCF-7-directed NK activity in the grade I tumor group (56.2%). Our results indicate that measurement of peripheral blood NK activity against a breast carcinoma-derived cell line (MCF-7) defines a disease-related natural cytotoxic acitivity which correlates better with prognostic tumor parameters (tumor grading) than NK activity as defined by the lysis of K 562 erythroleukemic cells. NK activity testing against breast carcinoma cell lines should be used to monitor natural cytotoxic activities in breast cancer patients and its modulation by different routes of treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00417836
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