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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 1010-1013 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Meningokokkensepsis ; Purpura fulminans ; Fibrinolyse ; Gewebeplasminogenaktivator ; Key words Meningococcemia ; Purpura fulminans ; Fibrinolysis ; Tissue plasminogen activator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A case of a 16 years old young man with meningococcemia, septic shock and purpura fulminans is presented. The clinical course was complicated by ischemia of both lower legs and feet as well as both cheeks. After successful restoration of circulation, the lower legs remained ischemic and loss was imminent. Therefore, fibrinolytic therapy with recombinant tissue plasminogen activator (rt-PA) was started: Both lower legs and feet could be preserved. All of the toes of the right foot, however, had to be amputated. Discussion: Fibrinolytic therapy with rt-PA should be considered as a therapeutic option in patients with meningococcemia and purpura fulminans with imminent loss of extremities. Optimal perfusion pressure and control of coagulation seems to be a prerequisite for successful fibrinolytic therapy. Care should be taken to avoid complications, especially intracerebral hemorrhage.
    Notes: Zusammenfassung Berichtet wird über den Krankheitsverlauf eines 16jährigen Jugendlichen, der akut an einer Meningokokkensepsis mit septischem Schock und Purpura fulminans erkrankte. Nach Stabilisierung des Herz-Kreislauf- Systems blieben die Wangen sowie die Unterschenkel und Füße beidseits ischämisch, so daß mit einem Verlust beider Unterschenkel und Füße gerechnet werden mußte. In dieser Situation wurde eine Fibrinolyse mit rekombinantem Gewebeplasminogenaktivator (rt-PA) durchgeführt: Beide Unterschenkel und Füße konnten erhalten werden, jedoch mußten alle Zehen des rechten Fußes amputiert werden. Diskussion: Bei Meningokokkensepsis mit Purpura fulminans erscheint eine Fibrinolyse bei ischämischen Extremitäten sinnvoll. Diese sollte allerdings u.E. erst nach Stabilisierung des Herz-Kreislauf-Systems und der Gerinnung erfolgen, da ansonsten weder der Effekt der Lyse noch mögliche Komplikationen, insbesondere Blutungen in das Zentralnervensystem, richtig erkannt werden können.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Keywords: Key words Granulocyte colony-stimulating factor receptor ; Flow cytometry ; Neonates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neutrophils are an essential component of the human host defence system against infection. Recombinant human granulocyte colony-stimulating factor induces neutrophilia and enhances effector functions of mature neutrophils. Since the biological effects of granulocyte colony-stimulating factor (G-CSF) are mediated by its receptor, we investigated the expression of G-CSF receptor on the surface of neutrophils of term and preterm neonates (n = 22) with and without signs of infection and of healthy adults (n = 13) by flow cytometry. In healthy adults, the percentage of neutrophils expressing G-CSF receptor was higher compared to cord blood of term and preterm neonates (87% vs 53%, P 〈 0.05). Between 2 and 32 h of life, neonates with signs of infection showed lower values of G-CSF receptor expression compared to neonates without signs of infection (32% vs 54%, P 〈 0.05). No correlation was detectable between expression of G-CSF receptor and gestational age. Conclusion Expression of granulocyte colony-stimulating factor receptor on neutrophils is lower than in adults. This may adversely affect granulopoiesis and neutrophil function during the neonatal period. Moreover, granulocyte colony-stimulating factor receptor expression seems to be down-regulated during neonatal infection.
    Type of Medium: Electronic Resource
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