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Digitale Medien

Triple helix-forming oligonucleotides which make imperfect Watson-Crick duplexes that compete with the creation of the triplex (1998)

Porumb, Horea ; Gousset, Hervé ; Taillandier, Eliane

Weinheim : Wiley-Blackwell

Electrophoresis 19 (1998), S. 2389-2390

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Details

ISSN: 0173-0835

Schlagwort(e): Gel retardation ; Dissociation constant ; Oligonucleotide association ; Human HER2 ; Neu oncogene targeting ; Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Chemie und Pharmazie

Notizen: Because of the repetitive nature of the sequence, when titrating a G,A-rich, triple helix-forming oligonucleotide (TFO) with increasing concentrations of target duplex in order to obtain the dissociation constant of the complex, a duplex is sometimes first generated at intermediate concentrations of the target. This duplex is based on an imperfect Watson-Crick pairing of the TFO to the pyrimidine-rich strand of the target. An explanation is proposed for this duplex being obtained only in a certain domain of the titration range, before the triple helix becomes predominant.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/elps.1150191404

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