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Digitale Medien

Remoxipride — a new potential antipsychotic drug (1988)

Farde, L. ; Grind, M. ; Nilsson, M.-I. ; [weitere]

Springer

Psychopharmacology 95 (1988), S. 157-161

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Details

ISSN: 1432-2072

Schlagwort(e): Remoxipride ; Neuroleptics ; Healthy volunteers ; Pharmacokinetics ; Akathisia

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Remoxipride, a new potential antipsychotic drug, was administered over 4 days at two dose levels, 70 and 140 mg t.i.d., to eight healthy male volunteers. Pharmacokinetics, safety, tolerability, and effect on plasma prolactin levels were evaluated. Remoxipride exhibited essentially linear pharmacokinetics. Only minor deviations in biochemical and physiological safety parameters were found. The drug was well tolerated by all subjects at the 70 mg dose level. At 140 mg akathisia appeared in seven subjects. The drug induced a rapid and transient increase in plasma prolactin concentrations at both dose levels after single doses. During steady state, a significant reduction in the prolactin response was observed as compared to after the first dose.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00174501

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