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  • Neutrophils  (1)
  • anticoccidiostatic agents  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Clinical trial of in-situ hybridization method for the rapid diagnosis of sepsis (1999)
    Springer
    Journal of infection and chemotherapy 5 (1999), S. 21-31 
    Details
    ISSN: 1437-7780
    Keywords: Key words SIRS ; Sepsis ; Bacteremia ; Neutrophils ; In-situ hybridization ; Blood culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the utility of in-situ hybridization (ISH) for the rapid diagnosis of sepsis. We applied this approach to polymorphonuclear neutrophil (PMN)-rich smears from patients with suspected bacterial infection. Positive results by ISH were obtained in the smears of 123 of 292 patients (42%), while only 32 of the 292 (11%) were positive by blood culture. These findings indicate that ISH is almost four times more sensitive than the culture method for the detection of sepsis. ISH results are obtained within 1 day, while 1 day to 2 weeks is required for the results of blood culture. Blood culture and ISH methods detected the same bacteria in two patients. ISH also successfully identified the same bacteria in blood and PMN-rich body fluid (bronchoalveolar lavage samples) in 6 patients. In 19 patients, ISH of blood detected the same bacteria as those found in subcultures from other sources (e.g., stool, sputum, nasal cavity). We discuss these results in comparison with blood culture results in terms of evaluating a rapid approach to the management of patients with sepsis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101560050004
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanistic effects of kijimicin on inhibition of human immunodeficiency virus replication (1993)
    Springer
    Molecular and cellular biochemistry 119 (1993), S. 35-41 
    Details
    ISSN: 1573-4919
    Keywords: viral replication ; anticoccidiostatic agents ; human immunodeficiency virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Kijimicin represents an important type of ionophore compound. In veterinary medicine, it is becoming important as anticoccidiostatic agent and feed supplement. We examined Kijimicin for its HIV inhibitory activity. The compound exhibited concentration-dependent inhibition of HIV replication in primary infected cultures of human T-lymphoblastoid H9 cells. Substantial inhibition of viral replication was observed at concentrations of Kijimicin that showed little cytotoxicity. The ratio of IC50 values for the MTT to RT assays was 40. Anti HIV activity was also observed in cultures of monocytic lineage U937 cells chronically infected with HIV. Moreover, in attempting to define the inhibitory mechanism of Kijimicin, we investigated its effect on each step of HIV replication. The infectivity of progeny viral particles was reduced by Kijimicin treatment. This decrease may be due to incompletely glycosylated forms of gp120.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00926851
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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