ISSN:
1432-1106
Keywords:
Renshaw cell
;
Acetylcholine receptors
;
Nicotinic
;
Muscarinic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The pharmacological properties of Renshaw cells in the lumbar spinal cord of cats anaesthetised with pentobarbitone have been investigated by administering cholinomimetics, acetylcholine antagonists and cholinesterase inhibitors electrophoretically from multibarrelled glass micropipettes. The excitatory action of acetylcholine, nicotine and carbamylcholine was due predominantly to interaction with nicotinic receptors and could be blocked by dihydro-β-erythroidine. Acetyl-β-methylcholine and dl-muscarine interact with muscarinic receptors which could be blocked specifically by intravenously administered atropine. In the presence of dihydro-β-erythroidine and atropine, cholinomimetics may depress, and subsequently excite Renshaw cells. A third type of receptor, which may be a component of the membrane of many types of mammalian nerve cells, has been proposed to account for this depression. The enhancement of the acetylcholine excitation of Renshaw cells by physostigmine, edrophonium and neostigmine was complicated by a direct excitant action which was probably due to a combination with nicotinic receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00234361
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