ISSN:
1432-2072
Keywords:
Key words Carbamazepine-10
;
11-epoxide
;
Carbamazepine-10
;
11-diol
;
Catecholamine secretion
;
Nicotinic acetylcholine receptor-associated ion channel
;
Voltage-dependent Na+ channel
;
N-type voltage-dependent Ca2+ channel
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We have recently reported inhibitory effects of carbamazepine (CBZ) on ion channel-mediated secretion of catecholamines in bovine adrenal medullary cells. Here, we report the effects of carbamazepine-10,11-epoxide (CBZ-E), an active metabolite of CBZ, and carbamazepine-10,11-diol (CBZ-D), a non-active metabolite, on 22Na+ influx, 45Ca2+ influx and catecholamine secretion in cultured adrenal medullary cells. CBZ-E, but not CBZ-D inhibited 22Na+ influx, 45Ca2+ influx and catecholamine secretion induced by carbachol or veratridine with a half-maximal inhibitory concentration (IC50) of 0.26 or 0.68 μg/ml, respectively. CBZ-E also inhibited high K+-evoked 45Ca2+ influx and catecholamine secretion (IC50 = 0.3 μg/ml), but CBZ-D did not. These findings suggest that CBZ-E, but not CBZ-D, attenuates catecholamine secretion by inhibiting nicotinic acetylcholine receptor-associated ion channels, voltage-dependent Na+ channels and voltage-dependent Ca2+ channels in the cells. This inhibition of CBZ-E as well as CBZ may be related to the clinical effects in neuropsychiatric disorders.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002130050524
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