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  • 1
    Electronic Resource
    Electronic Resource
    Zunahme des Leberblutflusses unter Nifedipin (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 1113-1118 
    Details
    ISSN: 1432-1440
    Keywords: Nifedipine ; Liver blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The hepatic hemodynamic effect of 20 mg sublingual nifedipine was evaluated in 15 patients (13 men, 2 women) during heart catheterization. The liver blood flow was measured 10 min after administration of nifedipine by continuous thermodilution (Baim coronary sinus flow analyzer). Nifedipine was associated with a decrease in systolic blood pressure (from 156+/−14 to 138+/−13 mmHg), an increase in heart rate from (73+/−13 to 81+/−8.6 beats/min), and increase in cardiac output (from 6.0+/−1.6 to 6.5+/−1.3 l/min). In 2/15 patients no significant change was derived. The liver blood flow increased in 13/15 patients from 218+/−171.7 to 336.7+/−247.7 ml/min (22%–194%,P〈0.01). The study demonstrates that the vasodilation of nifedipine involves the hepatic circulation. If the hepatic clearance of drugs is high and flow dependent, nifedipine-induced increase of hepatic blood flow may impair drug clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726871
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  • 2
    Electronic Resource
    Electronic Resource
    Erhöhtes atriales natriuretisches Peptid (ANP) bei essentieller Hypertonie — Abhängigkeit vom rechtsatrialen Druckverhalten (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 756-761 
    Details
    ISSN: 1432-1440
    Keywords: Atrial natriuretic peptide ; Hypertension ; Pulmonary resistance ; Pulmonary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of atrial natriuretic peptide (ANP) in the pathogenesis of essential hypertension has not yet entirely been clarified. We investigated whether the increase of ANP in essential hypertension may be explained by elevated right atrial pressures and/or a different relationship between right atrial pressures and ANP secretion. Patients with stable essential hypertension undergoing right and left heart catheterization because of suspected coronary heart disease had significantly higher ANP levels than normotensives: 58.7±6.7 pg/ml in hypertensives versus 42.0±4.1 pg/ml in normotensives (p〈0,01). Matching hypertensives with normotensives at identical levels of left ventricular enddiastolic pressure revealed significantly higher mean pulmonary artery pressures in hypertensives. Right atrial diastolic pressure (v-wave) after matching for LVEDP was 4.8±0.5 mm Hg in hypertensives and 3.1±0.2 mm Hg in normotensives (p〈0.05). In addition, at any given mean right atrial pressure hypertensives showed higher ANP levels than normotensives. These results demonstrate that hypertensives exhibit raised pressures in the pulmonary artery independent of left ventricular pressure load. The elevation in right atrial pressures and the steeper relationship between these pressures and ANP are a suitable explanation for raised ANP levels in hypertension. ANP in essential hypertension may represent a counterregulation against elevated pulmonary resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745345
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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