ISSN:
1432-0533
Keywords:
Key words Excitatory amino acids
;
N-Methyl-d-aspartate receptors
;
Nitric oxide
;
Arcuate nucleus
;
Monosodium glutamate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Glutamate-, aspartate-, N-methyl-d-aspartate receptor (NMDAR1 and 2 subunits)-, and nitric oxide synthase (NOS)-immunoreactive neurons were studied in the arcuate nucleus (AN) of mice treated neonatally with monosodium glutamate (MSG) which is known to cause extensive neuronal loss in this hypothalamic nucleus. It was found that intensely stained glutamate- and aspartate-immunoreactive neurons present in the AN of control mice were completely absent in the MSG-lesioned AN as well as the ventromedial nucleus lateral to the AN. Similarly, NMDAR1-immunoreactive neurons were mostly absent in the MSG-lesioned AN but remained intact in the ventromedial nucleus. There was also a substantial loss of NMDAR2 immunoreactivity within the AN. In contrast, NOS-immunoreactive neurons in the AN survived the neonatal glutamate treatment, although they appeared to be less intensely stained.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004010050752
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