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The Human Nm23/Nucleoside Diphosphate Kinases (2000)

Lacombe, Marie-Lise Laurence ; Munier, Annie ; Mehus, James G. ; [et al.]

Springer

Journal of bioenergetics and biomembranes 32 (2000), S. 247-258

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ISSN: 1573-6881

Keywords: Nm23 ; NDP kinase ; mitochondria ; testis ; dynein ; metastasis

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Physics

Notes: Abstract Biochemical experiments over the past 40 years have shown that nucleoside diphosphate(NDP) kinase activity, which catalyzes phosphoryl transfer from a nucleoside triphosphate toa nucleoside diphosphate, is ubiquitously found in organisms from bacteria to human. Overthe past 10 years, eight human genes of the nm23/NDP kinase family have been discoveredthat can be separated into two groups based on analysis of their sequences. In addition tocatalysis, which may not be exhibited by all isoforms, evidence for regulatory roles has comerecently from the discovery of the genes nm23 and awd, which encode NDP kinases and areinvolved in tumor metastasis and Drosophila development, respectively. Current work showsthat the human NDP kinase genes are differentially expressed in tissues and that their productsare targeted to different subcellular locations. This suggests that Nm23/NDP kinases possessdifferent, but specific, functions within the cell, depending on their localization. The roles ofNDP kinases in metabolic pathways and nucleic acid synthesis are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1005584929050

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cAMP-dependent protein kinase from Dictyostelium discoideum (1988)

Veron, Michel ; Mutzel, Rupert ; Lacombe, Marie-Lise ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

Developmental Genetics 9 (1988), S. 247-258

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ISSN: 0192-253X

Keywords: protein evolution ; lower eukaryote ; differentiation ; Life and Medical Sciences ; Genetics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: The cAMP-dependent protein kinase (cAK) from Dictyostelium discoideum is an enzyme composed of one catalytic and one regulatory subunit. Upon binding of cAMP, the holoenzyme dissociates to liberate free active catalytic subunits. The cAK is developmentally regulated, ranging from very little activity in vegetative cells to maximal expression in postaggregative cells. Although there is no immunological cross-reaction between the subunits of cAKs from Dictyostelium and from other organisms, they share several biochemical properties. A complete cDNA for the regulatory subunit has been cloned and sequenced. Only one copy of the gene for the regulatory subunit is present per haploid genome. On the basis of the comparison of the structure of the cAK from Dictyostelium with its counterparts in yeast and higher eukaryotes, we propose a model for the evolution of cyclic-nucleotide-binding proteins.

Additional Material: 3 Ill.