ISSN:
1435-1536
Keywords:
Key words Cholesterol
;
solubilization
;
HLB
;
mixed micelles
;
emulsions
;
critical micelle concentration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Abstract The solubilization of cholesterol by anionic surfactant mixtures was studied as a function of their HLB values. The relationship between the logarithm of the critical micelle concentration and the HLB value of the mixtures was not linear, which was attributed to a lack of strict additivity of the HLB values. The solubilized cholesterol/surfactant ratio was determined and it was found to be higher than that in bile salts in all the studied surfactant mixtures. Below HLB=24, emulsions were obtained, and the remaining cholesterol was solid. Above that value, limpid solutions were obtained, giving a solubility maximum at HLB≈35. The non-solubilized cholesterol was mainly in the form of lamellar mesophase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s003960050213
Permalink