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  • 1
    Electronic Resource
    Electronic Resource
    Conformation and packing differences between two anomeric xylofuranosyl uracil nucleosides: Crystal structure of α-C14N2O7H18 monohydrate (1995)
    Springer
    Journal of chemical crystallography 25 (1995), S. 123-128 
    Details
    ISSN: 1572-8854
    Keywords: Nucleoside ; hydrated nucleoside ; anomeric differences ; pyrimidine ; uracil ; xylofuranosyl ring ; isopropylidene rings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract 5-Acetyl-1-(3,5-O-isopropylidene-α-D-xylofuranosyl) uracil monohydrate (α-AXU·H2O) crystallizes in an orthorhombic cell of dimensionsa=7.286(6),b 14.281(10),c=15.852(11) Å. Its structure has been determined by direct methods from single-crystal CuK α X-ray data and refined to a conventionalR factor of 0.055 over 1708 unique reflections. The furanose ring has conformation C2'endo-C3'endo (rather than the uncommon C3'endo-C4'exo as in β-AXU) and the glycosidic torsion angle is −31° (17° in β-AXU). The oxygen of the water molecule in α-AXU·H2O accepts a hydrogen bond (O 10...O 5=2.70 Å) from the sugar hydroxyl O5 and the hydrogens form hydrogen bonds to a uracil carbonyl (O 10...O 2=2.78 Å) and an isopropylidene oxygen atom (O 10...O 7=2.90 Å).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01665987
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  • 2
    Electronic Resource
    Electronic Resource
    Differential cholinergic regulation in Alzheimer's patients compared to controls following chronic blockade with scopolamine: a SPECT study (1995)
    Springer
    Psychopharmacology 121 (1995), S. 231-241 
    Details
    ISSN: 1432-2072
    Keywords: Scopolamine ; Alzheimer's disease ; SPECT ; I-QNB ; HMPAO ; cholinergic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of low-dose chronic scopolamine on measures of cerebral perfusion and muscarinic receptors were tested in eight Alzheimer's disease (AD) subjects and eight elderly controls. Single photon emission computed tomography (SPECT) scans using technetium-labelled hexamethypropylene amine oxide (99mTc-HMPAO) to measure cerebral perfusion before and after chronic scopolamine revealed a significant 12% increase in the normal controls (P〈0.01) while the AD subjects showed no significant change. In contrast, the controls showed decreased muscarinic binding as evidenced by123I-quinuclidinyl-4-iodobenzilate (123I-QNB) labelling after chronic drug (−10%,P〈0.01) whereas the AD subjects showed increased123I-QNB labelling (+8%,P〈0.05). The difference between AD and control subjects was even more marked when the ratio of I-QNB to HMPAO uptake was compared, pointing to a double dissociation in the SPECT results. These data cannot be explained by group differences in cerebral perfusion alone and suggest a differential sensitivity between AD and elderly controls to chronic cholinergic blockade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245634
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    Paper (German National Licenses)
    Fulltext
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