ISSN:
1432-2234
Keywords:
Key words: (
;
)-Deprenyl
;
Oxidative stress
;
OH
;
OOH
;
Radical scavenger
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract. The chemical reactions between (−)-deprenyl and ·OH or ·OOH were studied using molecular orbital theory, with N,N-dimethylpropargylamine as a model. (−)-Deprenyl was confirmed to be a good radical scavenger. The active site was the acetylenic part and ·OH- or ·OOH was trapped on either acetylenic carbon. The activation energies were about 10–20 kcal/mol. The resulting ·OH- or ·OOH-adducts, still radicals, trapped further radicals on the remaining carbon of the acetylenic part. The final double trapping products were at extraordinarily lower energy levels than the original reactants by 50–70 kcal/mol. The secondary transition states were not detected, suggesting that the reactions occurred at once or in a cascade. Some results with the model system were verified by the results with the real (−)-deprenyl system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002140000161
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