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  • 1
    ISSN: 1573-2568
    Keywords: OXYGEN FREE RADICALS ; LIPID PEROXIDATION ; CERULEIN ; PANCREATITIS ; MELATONIN
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since oxygen free radicals and lipidperoxidation have been implicated in the pathogenesis ofan early stage of acute pancreatitis, we examinedwhether melatonin, a recently discovered free-radicalscavenger, could attenuate pancreatic injury inSprague-Dawley rats with cerulein-induced pancreatitis.Acute pancreatitis was induced by four intraperitonealinjections of cerulein (50 μg/kg body wt) given at1-hr intervals. Thirty minutes after the lastcerulein injection, the rats were killed and the degreeof pancreatic edema, the level of lipid peroxidation inthe pancreas, and serum amylase activity were increased significantly. Pretreatment with melatonin (10or 50 mg/kg body wt) 30 min before each ceruleininjection resulted in a significant reduction inpancreatic edema and the levels of lipid peroxidation.Serum amylase activity, however, was notsignificantly influenced by either dose of melatonin.Moreover, we found that cerulein administration wasassociated with stomach edema as well as high levels oflipid peroxidation in the stomach and smallintestine, which were also reduced by melatonin.Melatonin's protective effects in cerulein-treated ratspresumably relate to its radical scavenging ability andto other antioxidative processes induced bymelatonin.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7330
    Keywords: in vitro fertilization-embryo transfer (IVF-ET) ; natural-cycle IVF ; cryopreserved-thawed ET ; simultaneous program of natural-cycle IVF and cryopreserved-thawed ET (NICE) ; pregnancy rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: This clinical study was designed to identify and compare the pregnancy rates of simultaneous program of natural-cycle IVF and cryopreserved-thawed ET (NICE) with those of natural-cycle IVF and cryopreserved-thawed ET. Methods: All three groups comprised spontaneously ovulating infertile women under the age of 40 and without any male factor present. The NICE program was performed in 36 patients (47 cycles) who had previously undergone IVF-ET resulting in cryopreserved embryos. As control groups, the natural-cycle IVF was performed in 45 patients (80 cycles), and the cryopreserved-thawed ET alone in 29 patients (40 cycles). Results: The cancellation rate of the initiated cycles prior to ET was 19.1% (9/47) in the NICE group, 23.8% (19/80) in the natural-cycle IVF group, and 2.5% (1/40) in the cryopreserved-thawed ET group. The mean number of embryos transferred was 4.0±1.1 (2–5) in the NICE group, 1.0 in the natural-cycle IVF group, and 4.2±1.8 (1–5) in the cryopreserved-thawed ET group. The clinical pregnancy rates per aspiration cycle (32.5%) and per ET cycle (34.2%) in the NICE group were significantly higher than those (14.9, 16.4%) in the natural-cycle IVF group. The clinical and delivered pregnancy rates per ET (34.2, 26.3%) in the NICE group were higher than those (20.5, 15.4%) in the cryopreserved-thawed ET group, without statistical significance. Conclusions: Since the NICE program results in saving the fresh oocyte for patients participating in cryopreserved-thawed ET, more favorable pregnancy rates may be obtained from NICE cycles in women ovulating normally who had previously undergone IVF-ET with embryo cryopreservation.
    Type of Medium: Electronic Resource
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