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  • Oligoastrocytoma  (1)
  • Rat glioma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The additive effect ofα-difluoromethylornithine (DFMO) and radiation therapy on a rat glioma model (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 171-175 
    Details
    ISSN: 1432-1335
    Keywords: α-Difluoromethylornithine ; Radiation therapy ; Polyamines ; Rat glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of α-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greater effect on the survival rate than the single therapies, the effect being additive. The concentration of putrescine, spermidine, andN 1-acetylspermidine in tumor tissues was lowered by DFMO, while that of spermine was slightly elevated. Radiation decreased the concentration of all the polyamines, putrescine, spermidine, spermine andN 1-acetylspermidine. The concomitant treatment with DFMO and radiation further decreased the concentrations of putrescine andN 1-acetylspermidine in tumor tissues. The survival period of glioma-bearing rats is inversely correlated with the tissue levels of putrescine plusN 1-acetylspermidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410129
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinicohistological study of oligodendroglioma and oligoastrocytoma (1997)
    Springer
    Brain tumor pathology 14 (1997), S. 35-39 
    Details
    ISSN: 1861-387X
    Keywords: Oligodendroglioma ; Oligoastrocytoma ; Minigemistocyte ; Recurrence ; Outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for oligodendroglioma (four patients), 12.7 years for anaplastic oligodendroglioma (five patients), 13.5 years for oligoastrocytoma (seven patients), and 4.8 years for anaplastic oligoastrocytoma (four patients). Two of three recurrent oligodendrogliomas and two of two recurrent oligoastrocytomas showed malignant transformation. Minigemistocytes were sometimes recognized in recurrent tumors and had a sinister prognosis. Oligodendroglioma and oligoastrocytoma may transform into each other at recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02478866
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    Paper (German National Licenses)
    Fulltext
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