ISSN:
1573-3904
Keywords:
Oligonucleotide–peptide conjugate
;
Cellular uptake
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract We describe the solid phase synthesis of anamphipathic peptide C-terminated by a cysteamide groupwhich allows further addition after removal from theresin and cleavage of the side-chain protectinggroups. The peptide is shown to be rapidlyinternalized by cells with a nuclear localization ofthe peptide. When the peptide is linked to anoligonucleotide, the conjugate is also internalizedwith a final localization that is mainly cytoplasmic.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008851527983
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