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  • Open Field  (2)
  • Open Field Test  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of LSD on open field performance in rats (1969)
    Springer
    Psychopharmacology 15 (1969), S. 333-340 
    Details
    ISSN: 1432-2072
    Keywords: LSD ; Open Field Test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary LSD has been reported to have variable actions on locomotor and exploratory activity in rats. In the present study LSD in doses ranging from 2 to 500 μg/kg induced varying effects on different components of Open Field behaviour. The “ambulation score” showed a linear increase with increasing log doses while the highest dose caused a steep rise. The “rearing” and “preening scores” exhibited an inverted U type dose-response relationship, the inversion of the curve occuring with doses higher than 8 μg/kg. It is suggested that LSD in normal doses increases all stereotyped activity whereas with higher doses only simple stereotyped activity is increased. Simple horizontal stereotyped activity therefore increases at the cost of vertical stereotype. Thus LSD increases stereotyped activity with increasing dose but while normal doses increase both the horizontal and the vertical type of activity, the higher doses increase only the horizontal type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401687
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Modification of the effects of antipsychotic agents on the “Open Field” performance of rats by treatment with α-methyl tyrosine or p-chlorophenylalanine (1970)
    Springer
    Psychopharmacology 17 (1970), S. 361-366 
    Details
    ISSN: 1432-2072
    Keywords: Open Field
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were performed to study the effect on “Open Field” behaviour of subthreshold doses of reserpine and chlorpromazine in rats with lowered brain catecholamine or 5-hydroxytryptamine levels. The doses of α-methyltyrosine which are known to lower brain catecholamine contents by 65% remarkably enhanced the effects of antipsychotic agents on ambulation and rearing responses. These effects could be partially antagonized by simultaneous administration of L-DOPA. The lowering of 5-hydroxytryptamine to the extent of 90% by p-chlorophenylalanine failed to modify the effects of these antipsychotic agents. The findings suggest that the brain catecholamines levels play a greater role in the mechanism of antipsychotic agents as compared to 5-hydroxytryptamine levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403807
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    On the mechanism of potentiation of amphetamine induced stereotype behaviour by imipramine (1972)
    Springer
    Psychopharmacology 27 (1972), S. 367-372 
    Details
    ISSN: 1432-2072
    Keywords: Open Field ; Amphetamine ; Imipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were performed to study the individual and combined effects of amphetamine and imipramine in rats with lowered brain catecholamines or 5-HT levels. The stereotyped behaviour was studied employing the “Open Field” test apparatus. When the brain catecholamine level was lowered by α-methyl tyrosine, amphetamine failed to induce complex stereotyped behaviour, while disulfiram pretreatment did not significantly alter the complex stereotyped behaviour due to amphetamine. However, pretreatment with either α-methyltyrosine or p-chlorophenylalanine modified the effects of imipramine. Imipramine augmented the amphetamine induced stereotype behaviour. Pretreatment with α-methyl tyrosine, p-chlorophenylalanine or disulfiram altered the behavioural effects due to the interaction of imipramine and amphetamine. These findings suggest that catecholamines, particularly brain dopamine, play a greater role in the stereotype behaviour due to amphetamine and its augmentation by imipramine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429390
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    Paper (German National Licenses)
    Fulltext
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