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  • 1
    Electronic Resource
    Electronic Resource
    Modification of the effects of antipsychotic agents on the “Open Field” performance of rats by treatment with α-methyl tyrosine or p-chlorophenylalanine (1970)
    Springer
    Psychopharmacology 17 (1970), S. 361-366 
    Details
    ISSN: 1432-2072
    Keywords: Open Field
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were performed to study the effect on “Open Field” behaviour of subthreshold doses of reserpine and chlorpromazine in rats with lowered brain catecholamine or 5-hydroxytryptamine levels. The doses of α-methyltyrosine which are known to lower brain catecholamine contents by 65% remarkably enhanced the effects of antipsychotic agents on ambulation and rearing responses. These effects could be partially antagonized by simultaneous administration of L-DOPA. The lowering of 5-hydroxytryptamine to the extent of 90% by p-chlorophenylalanine failed to modify the effects of these antipsychotic agents. The findings suggest that the brain catecholamines levels play a greater role in the mechanism of antipsychotic agents as compared to 5-hydroxytryptamine levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403807
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On the mechanism of potentiation of amphetamine induced stereotype behaviour by imipramine (1972)
    Springer
    Psychopharmacology 27 (1972), S. 367-372 
    Details
    ISSN: 1432-2072
    Keywords: Open Field ; Amphetamine ; Imipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were performed to study the individual and combined effects of amphetamine and imipramine in rats with lowered brain catecholamines or 5-HT levels. The stereotyped behaviour was studied employing the “Open Field” test apparatus. When the brain catecholamine level was lowered by α-methyl tyrosine, amphetamine failed to induce complex stereotyped behaviour, while disulfiram pretreatment did not significantly alter the complex stereotyped behaviour due to amphetamine. However, pretreatment with either α-methyltyrosine or p-chlorophenylalanine modified the effects of imipramine. Imipramine augmented the amphetamine induced stereotype behaviour. Pretreatment with α-methyl tyrosine, p-chlorophenylalanine or disulfiram altered the behavioural effects due to the interaction of imipramine and amphetamine. These findings suggest that catecholamines, particularly brain dopamine, play a greater role in the stereotype behaviour due to amphetamine and its augmentation by imipramine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429390
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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