ISSN:
0935-6304
Keywords:
Capillary gas chromatography
;
Nitrogen selective detector
;
Urine clean-up
;
Heroin metabolite
;
O6-Monoacetylmorphine
;
Opiates
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Three methods were evaluated for the determination of O6-monoacetylmorphine (6-MAM), the specific metabolite of heroin in human urine, by GC-NPD-FID. The procedure devised for a hydrophobic cation exchange column showed superior performances over the liquid-liquid extraction technique and solid phase extraction with C18. 6-MAM can be analyzed in random urines at the 2 ng/mL concentration with classical equipment for the differentiation between heroin intake and opiates from various origins. The procedure was also applied to enzymatic and acid hydrolyzates of urines. The simultaneous presence of morphine and codeine are useful in the interpretation of results.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240130304
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