ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A cyclic pentapeptide containing an energy donor group and an energy acceptor group within the molecule, cyclo [Trp-Sar-Sar-Lys (DNS)-Pro], was synthesized. Its conformation, complexation with metal ions, intramolecular energy transfer, and interaction with liposomes were investigated. The precursor, cyclo [Trp-Sar-Sar Lys (Z)-Pro], contained one cis-sarcosyl peptide bond and a β-turn in which the Pro-residue occupied the 3rd position. This cyclic pentapeptide formed a complex selectively with Ba2+ and its binding constant in 95% aqueous methanol solution was 2.0 × 103 1 · mol-1. The intramolecular energy-transfer efficiency of cyclo [Trp-Sar-Sar-Lys (DNS)-Pro] was almost constant between - 60° and 40° in ethanol, while it increased at temperatures lower than 34° in liposomes as a result of the pre-transition of the lipid assembly. On the other hand, the intramolecular energy transfer efficiency of cyclo [Trp-Sar-Sar-Lys (DNS)-Pro] decreased upon complexation with Ba2+.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19820650808
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