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  • 1
    Electronic Resource
    Electronic Resource
    Biologically active glycosides from asteroidea, XXXII. Glycosphingolipids from the starfish Astropecten latespinosus, 2. Structure of two new ganglioside molecular species and biological activity of the ganglioside (1995)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1995 (1995), S. 545-550 
    Details
    ISSN: 0947-3440
    Keywords: Glycosphingolipids ; Gangliosides ; Starfish ; Astropecten latespinosus ; Antitumor activity ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two ganglioside molecular species [LG-1 (1) and LG-2 (5)] have been obtained from the water-soluble lipid fraction of the chloroform/methanol extract of the starfish Astropecten latespinosus. On the basis of chemical and spectroscopic findings, the structure of 1 and 5 have been elucidated. They are new ganglioside molecular species. Negative FAB mass spectrometry provided important information both on the structure of the sugar moiety and on the molecular mass of the gangliosides. Partial hydrolysis by hot water has proved useful for structure elucidation of the complex oligosaccharide moieties. In addition, the major ganglioside molecular species, LG-2 (5), shows antitumor activity against murine lymphoma L1210 cells in vitro.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199519950374
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  • 2
    Electronic Resource
    Electronic Resource
    Biologically active glycosides from asteroidea, XVI. Steroid oligoglycosides from the starfish Asterina pectinifera Müller et Troschel, 3 structures of two new oligoglycoside sulfates, pectiniosides E and F, and biological activities of the six new pectiniosides (1988)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1988 (1988), S. 845-850 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Biologisch aktive Glycoside aus Asteroidea, XVI.  -  Steroid-Oligoglycoside aus dem Seestern Asterina pectinifera Müller et Troschel, 3. - Die Strukturen von zwei neuen Oligoglycosidsulfaten, Pectiniosid E und F sowie die biologischen Aktivitäten der sechs neuen PectiniosideAus dem wäßrigen Extrakt der ganzen Seesterne Asterina pectinifera Müller et Troschel konnten nach chromatographischen Trennungen an Kieselgel RP-8 und Sephadex LH-20 zwei weitere neue Oligoglycosidsulfate, Pectiniosid E (1) und F (2), isoliert werden. Auf Grund chemischer und spektroskopischer Beweise wurden die Strukturen von 1 und 2 ermittelt. Außerdem wurde der Antitumoreffekt der Glycosidsulfate Pectiniosid A, B, C, D, E und F gegen die Mäuse-Lymphoma-L1210-Zelle und Human-Epidermoid-Carcinoma-KB-Zelle in vitro untersucht.
    Notes: Two further new oligoglycosides sulfates named pectinioside E (1) and F (2) were isolated from aqueous extracts of the whole bodies of Asterina pectinifera Müller et Troschel, after separation by column chromatography on silica gel, RP-8, and Sephadex LH-20. Their structures have been elucidated by chemical and spectroscopic means. In addition, we examined the antitumor effect of pectiniosides A, B, C, D, E, and F against murine lymphoma L1210 cells and human epidermoid carcinoma KB cells in vitro.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198819880905
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  • 3
    Electronic Resource
    Electronic Resource
    Biologically active glycosides from asteroidea, XVIII. 1H-NMR spectroscopy and biological activities of polyhydroxylated steroids from the starfish Asterina pectinifera Müller et Troschel (1988)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1988 (1988), S. 1185-1189 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Biologisch aktive Glycoside aus Asteroidea, XVIII. - 1H-NMR-Spektroskopie und biologische Aktivitäten der polyhydroxylierten Steroide aus dem Seestern Asterina pectinifera Müller et TroschelDie aus dem Seestern Asterina pectinifera Müller et Troschel erhaltenen Acetate von polyhydroxylierten Steroiden wurden 1H-NMR-spektroskopisch untersucht. Die 1H-NMR-Spektren von fünf Acetaten polyhydroxylierter Cholestane wurden in Deuteriochloroform- und Deuteriopyridin-Lösungen gemessen und verglichen. Es wurden deutliche Unterschiede zwischen den Spektren in beiden Lösungsmitteln beobachtet. Die Spektren in Deuteriopyridin lieferten mehr Informationen zur Struktur der ursprünglichen polyhydroxylierten Cholestane als die in Deuteriochloroform. Isolierung und Strukturaufklärung der zwei neuen polyhydroxylierten Cholestane 1 und 8 werden ebenfalls beschrieben. Außerdem wurden die Antitumor-Aktivitäten einiger polyhydroxylierter Steroide dieses Seesterns untersucht.
    Notes: The acetates of polyhydroxylated steroids obtained from the starfish Asterina pectinifera Müller et Troschel were studied by 1H-NMR spectroscopy. The 1H-NMR spectra of five kinds of acetates of polyhydroxylated cholestanes were measured in deuteriochloroform and deuteriopyridine solutions and then compared. Marked differences were observed between the spectra obtained in both solvents. The spectra in deuteriopyridine were more useful than those in deuteriochloroform in providing information on the structure of the parent polyhydroxylated cholestanes. The isolation and structures of the two new polyhydroxylated cholestanes 1 and 8 are also described. Moreover, the antitumor activities of some polyhydroxylated steroids from this starfish were examined.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198819881214
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  • 4
    Electronic Resource
    Electronic Resource
    Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata (1990)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1990 (1990), S. 453-460 
    Details
    ISSN: 0170-2041
    Keywords: Cucumaria echinata ; Sea cucumber ; Cucumariidae ; Triterpenoid glycoside sulfate ; Holostane derivative ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: From the whole body of sea cucumber Cucumaria echinata (Cucumariidae), we recently identified six genuine holostane-type triterpenoid glycoside sulfates designated as cucumechinoside A (1), B (2), C (3), D (4), E (5), and F (6). The structures 1-6 were determined on the basis of chemical and spectral investigations. Antitumor activities of these cucumechinosides and their solvolized compounds (10, 11, and 12) against murine lymphoma L 1210 and human epidermoid carcinoma KB cell in vitro were examined, and their antifungal and antiprotozoal activities were also investigated.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199019900186
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