Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Immunoelectron microscopy of Rosenthal fibers (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 503-509 
    Details
    ISSN: 1432-0533
    Keywords: Rosenthal fibers ; Ubiquitin ; Immunohistochemistry ; Glial fibrillary acidic protein ; Vimentin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seventeen intracerebral gliomas containing Rosenthal fibers (RF) were studied by an immunoperoxidase method for localization of ubiquitin (UB), glial fibrillary acidic protein (GFAP), desmin and vimentin (VIM). The majority of RF showed an immunohistochemically negative core surrounded by a ring of overlapping reactions for UB, GFAP and VIM. Many RF were entirely negative for UB and intermediate filaments (IF). Immunoelectron microscopic lozalization of UB and GFAP was performed on seven selected tumors. UB was found in all RF and on IF in the proximity of RF. GFAP reaction was localized on astrocytic IF, including those trapped within RF, and within the granular component of some RF. In contrast to the light microscopic studies, neither GFAP-nor UB-negative RF were found on immunoelectron microscopy. VIM reaction on IF and a few RF was demonstrated in one tumor processed at low temperature into Lowicryl; it was much weaker than that for GFAP. Many cells with RF contained lysosome-like inclusions with material displaying electron density similar to adjacent RF; few of these inclusions were reactive for UB. It is concluded that RF formation is associated with ubiquitination of astrocytic IF. GFAP-and VIM-immunoreactive IF and products of their disintegration contribute to RF material. It is also suggested that the lysosomal system of astrocytes partially degrades RF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310130
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Phase II Studies of RMP-7 and Carboplatin in the Treatment of Recurrent High Grade Glioma (1999)
    Springer
    Journal of neuro-oncology 44 (1999), S. 137-145 
    Details
    ISSN: 1573-7373
    Keywords: glioma ; RMP-7 ; carboplatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The selective bradykinin analogue, RMP-7, transiently increases the permeability of the blood brain barrier and the delivery of hydrophilic agents into brain tumours. In 87 recurrent glioma patients (WHO Grade III/IV, median age 46, Karnofsky 70%) clinical and Magnetic Resonance Imaging (MRI) responses to i.v. cycles (q 28 days) of RMP-7 (300 ng/kg given as a 10 min infusion) and carboplatin (AUC 4-9) were assessed. 45 of these patients were chemotherapy naive (CN-RMP) and 42 had received one prior course of chemotherapy (CP-RMP). Neurological impairment, performance status and steroid use were measured prior to dosing at each cycle and tumour volume by 3-D MRI at the end of cycles 2, 4, 6, 9 and 12. Clinical evaluation of response demonstrated that 61% of CN-RMP patients were either stable or improved whilst this was 39% for CP-RMP patients, of which 37% and 8% improved respectively. Radiological evaluation showed 79% of CN-RMP patients were either stable, partial or complete responses and 24% for CP-RMP patients, of which 32% and 5% were CR or PR respectively. The median duration of response was 30.3 weeks in CN-RMP patients and 19.6 weeks in the CP-RMP group. Lack of response was associated with substantial baseline tumour volume. Drug toxicity was as previously reported for carboplatin. 11 patients had treatment-associated transient focal seizures. These results indicate that RMP-7 and carboplatin have significant activity in recurrent malignant glioma following radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006379332212
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Iowa European corn borer sex pheromone isolation and identification of four C14 esters (1977)
    Springer
    Journal of chemical ecology 3 (1977), S. 447-459 
    Details
    ISSN: 1573-1561
    Keywords: sex pheromones, European corn borer ; Ostrinia nubilalis ; acetate esters ; gas chromatography ; mass spectrometry ; gel-permeation chromatography ; liquid chromatography ; (Z)-11-tetradecenyl acetate ; (E)-11-tetradecenyl acetate ; (E)-9-tetradecenyl acetate ; tetradecyl acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Four C14 straight-chain acetate esters—(Z)-11-tetradecenyl acetate, (E)-11-tetradecenyl acetate, (E)-9-tetradecenyl acetate, and tetradecyl acetate—were isolated and identified from the diethyl ether extracts of the abdominal tips of adult female European corn borers,Ostrinia nubilalis (Hübner). The compounds were isolated using a combination of high-resolution gel-permeation, adsorption highpressure liquid, and micropreparative gas chromatography. Identifications were made by gas chromatography, a combination of gas chromatography and mass spectrometry, and microdegradative chemical methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00988187
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...