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Acute keratinocyte damage stimulates platelet-activating factor production (2000)

Alappatt, C. ; Johnson, C. A. ; Clay, K. L. ; [et al.]

Springer

Archives of dermatological research 292 (2000), S. 256-259

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ISSN: 1432-069X

Keywords: Key words Platelet-activating factor ; Oxidative stress ; Keratinocytes ; Mass spectrometry

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Recent evidence suggests that the phosphocholine-derived lipid mediator platelet-activating factor (PAF) is involved in keratinocyte function and cutaneous inflammation. PAF is found in various inflammatory skin diseases, and intradermal injection of PAF directly results in cutaneous inflammation. Keratinocytes also synthesize PAF and related 1-acyl species in response to ionophores, cytokines and growth factors, and in response to activation of the epidermal PAF receptor. Since keratinocytes are routinely exposed to potential damage by thermal or oxidative stressors with resultant induction of cutaneous inflammation, the objective of these studies was to assess whether exogenous thermal or oxidative damage can induce the production of PAF and related 1-acyl species. Cells of the immortalized human keratinocyte cell line HaCaT were subjected to acute heat or cold, or treatment with the pro-oxidant lipid tertiary butyl hydroperoxide, and PAF and 1-palmitoyl-2-acetyl-GPC were measured by gas chromatography/mass spectrometry. We report that these diverse toxic stimuli resulted in the accumulation of these biologically active lipids. These studies suggest that the PAF system is involved in the inflammatory response seen following acute epidermal damage.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004030050483

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Carbon-nitrogen bond dissociation energy values in C-nitrosocompounds (1972)

Carmichael, P. J. ; Gowenlock, B. G. ; Johnson, C. A. F.

New York, NY : Wiley-Blackwell

International Journal of Chemical Kinetics 4 (1972), S. 339-343

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ISSN: 0538-8066

Keywords: Chemistry ; Physical Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Measurements of the D(R—NO) bond strength in some C-nitrosocompounds have been made using an electron impact method. The appearance potential of the radical ion (R+) has been determined, the D(R—NO) bond energy being obtained from the relation \documentclass{article}\pagestyle{empty}\begin{document}$$D{\rm (R} - {\rm NO) = }AP{\rm (R}^{\rm + } {\rm)} - IP({\rm R}.)$$\end{document} The values obtained are: D(C6H5—NO) = 41 kcal/mole, D(t-C4H9—NO) = 34 kcal/mole, D(t-C5H11—NO) = 36 kcal/mole and D(i-C3H7—NO) = 36.5 kcal/mole. These values are in good agreement with the numerous estimations of Benson and coworkers and confirm that the C—N bond strength in C-nitrosocompounds is very much less than in nitrocompounds or in amines.

Additional Material: 3 Tab.